fatty liver. This overflow paradigm perfectly explains the central paradox. Looking at blood glucose, the cell appears insulin resistant. Looking at DNL, the cell appears to have enhanced insulin sensitivity. This happens in the liver cell, with the same level of insulin and the same insulin receptors. The paradox has been resolved by understanding this new paradigm of insulin resistance. The cell is not internally starved; it is overloaded with glucose. The physical manifestation of that cell—overstuffed with excess glucose, now turned into fat via DNL—can be seen as fatty infiltration of the
...more
