WHEREAS MOST DISEASES are limited to a single organ system, diabetes affects every organ in multiple ways. As a result, it is the leading cause of blindness. It is the leading cause of kidney failure. It is the leading cause of heart disease. It is the leading cause of stroke. It is the leading cause of amputations. It is the leading cause of dementia. It is the leading cause of infertility. It is the leading cause of nerve damage.