sodium-glucose cotransporter 2 (SGLT2) inhibitors, block glucose reabsorption in the kidney, allowing glucose to escape in the urine, which replicates the protective mechanism used by the body during severe hyperglycemia. What happens if you don’t block this protective mechanism, but enhance it? Where the classic diabetes drugs increase insulin, the SGLT2 inhibitors lower it21 by forcing the excretion of glucose outside the body.
