GLUCAGON-LIKE PEPTIDE 1 (GLP-1) analogs are diabetic medications that mimic the effect of the incretin hormones. Normally, the incretins secreted by the stomach have several physiological roles when you eat food. They increase the release of insulin but also slow down the motility of the stomach and increase satiety. The DPP-4 inhibitors also enhance incretin levels, but the GLP-1 analogs reach levels that are many times higher than normal. Incretins increase the insulin response to food, so blood glucose decreases after meals. This transitory rise in insulin is not enough to cause weight
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