In a typical patient, gaining as little as 2 kilograms (4.4 pounds) of weight is the first detectable abnormality related to hyperinsulinemia/insulin resistance, followed by low HDL cholesterol levels. High blood pressure, fatty liver, and high triglycerides emerge next, at roughly the same time. The very last symptom to appear is usually high blood glucose, which clinches the diagnosis of type 2 diabetes.
