Acarbose, SGLT2 inhibitors, and GLP-1 analogs all lower glucose but also lower insulin and cause weight loss. Since type 2 diabetes is a disease characterized by elevations in both blood glucose and blood insulin, these medications would be predicted to have the best outcome. And sure enough, that is the case. In a disease of too much insulin, lowering it creates benefits. These three categories of medications could easily be called the good (lowers insulin, body weight, and complications), the bad (neutral), and the ugly (increases insulin, body weight, and complications).
