A similar review in the Journal of the American Medical Association that included all relevant trials up to March 2016 found that none of the drug classes considered, including metformin, SUs, TZDs, and DPP-4 inhibitors, reduced cardiovascular disease or other complications.30 Importantly, these older medications did not reduce the hyperinsulinemia that is the root problem, or indeed, made it worse. Again, diabetes will continue unless we treat the root cause.
