The researchers identified two genes that are disrupted by the translocation: DISC1 (disruption in schizophrenia 1) and DISC2 (disruption in schizophrenia 2). Although this particular translocation has been found in only one family, that family’s unusually high incidence of psychiatric disorders suggests that these two genes, and other genes close to where the chromosomes broke, may be responsible for psychotic symptoms in schizophrenia and in mood disorders.
