Mark Gerstein

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An animal model of a disorder can be engineered in two ways. One, as we have seen, is by identifying the genes in an animal that are equivalent to the human genes thought to contribute to a disorder, altering those animal genes, and then observing the effects on the animal. The second is by inserting a human gene into an animal’s genome to see whether it produces the same effects in the animal as in people.
The Disordered Mind: What Unusual Brains Tell Us About Ourselves
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