Yes, “the toad,” or to be more precise, the smoked venom of the Sonoran Desert toad (Incilius alvarius), also called the Colorado River toad, which contains a molecule called 5-MeO-DMT that is one of the most potent and fast-acting psychotropic drugs there is. No, I had never heard of it either. It is so obscure, in fact, that the federal government did not list 5-MeO-DMT as a controlled substance until 2011.

