How to Change Your Mind: The New Science of Psychedelics

by Michael Pollan

‘Michael walks the tight-rope between an objective “reporter” and a spiritual pilgrim

Nice way to define balancing between extremes ends.

travel guide for their renaissance’

utility : while speaking

The first of these molecules was an accidental invention of science. Lysergic acid diethylamide, commonly known as LSD, was first synthesized by Albert Hofmann in 1938, shortly before physicists split an atom of uranium for the first time. Hofmann, who worked for the Swiss pharmaceutical firm Sandoz, had been looking for a drug to stimulate circulation, not a psychoactive compound. It wasn’t until five years later when he accidentally ingested a minuscule quantity of the new chemical that he realized he had created something powerful, at once terrifying and wondrous. The second molecule had been around for thousands of years, though no one in the developed world was aware of it. Produced not by a chemist but by an inconspicuous little brown mushroom, this molecule, which would come to be known as psilocybin, had been used by the indigenous peoples of Mexico and Central America for hundreds of years as a sacrament. Called teonanácatl by the Aztecs, or “flesh of the gods,” the mushroom was brutally suppressed by the Roman Catholic Church after the Spanish conquest and driven underground. In 1955, twelve years after Albert Hofmann’s discovery of LSD, a Manhattan banker and amateur mycologist named R. Gordon Wasson sampled the magic mushroom in the town of Huautla de Jiménez in the southern Mexican state of Oaxaca. Two years later, he published a fifteen-page account of the “mushrooms that cause strange visions” in Life magazine, marking the moment when news of a new form of c...

History of Psychedelics : a) LSD b) Psylocilin

The dark side of psychedelics began to receive tremendous amounts of publicity—bad trips, psychotic breaks, flashbacks, suicides—and beginning in 1965 the exuberance surrounding these new drugs gave way to moral panic. As quickly as the culture and the scientific establishment had embraced psychedelics, they now turned sharply against them. By the end of the decade, psychedelic drugs—which had been legal in most places—were outlawed and forced underground.

why psychedics got banned in the 60's

Beginning in the 1990s, well out of view of most of us, a small group of scientists, psychotherapists, and so-called psychonauts, believing that something precious had been lost from both science and culture, resolved to recover it.

comeback of psychedlics

wonderfully italicized version of the familiar reality.

utility: writing

I was gripped by a powerful compulsion to be outdoors, undressed, and as far from anything made of metal or plastic as it was possible to get.

“set” and “setting.” Set is the mind-set or expectation one brings to the experience, and setting is the environment in which it takes place.

important of set and setting

soon after Timothy Leary’s Harvard Psilocybin Project crashed and burned in 1963.

What was most remarkable about the results reported in the article is that participants ranked their psilocybin experience as one of the most meaningful in their lives, comparable “to the birth of a first child or death of a parent.” Two-thirds of the participants rated the session among the top five “most spiritually significant experiences” of their lives; one-third ranked it the most significant such experience in their lives. Fourteen months later, these ratings had slipped only slightly. The volunteers reported significant improvements in their “personal well-being, life satisfaction and positive behavior change,” changes that were confirmed by their family members and friends.

Findings in the psychdic research of 2006

virginal noticing,

Utility word

but they do seem to be one of the easier knobs to take hold of and turn.

utility note

If the start of the modern renaissance of psychedelic research can be dated with any precision, one good place to do it would be the year 2006. Not that this was obvious to many people at the time. There was no law passed or regulation lifted or discovery announced to mark the historical shift. But as three unrelated events unfolded during the course of that year—the first in Basel, Switzerland, the second in Washington, D.C., and the third in Baltimore, Maryland—sensitive ears could make out the sound of ice beginning to crack. The first event, which looked back but also forward like a kind of historical hinge, was the centennial of the birth of Albert Hofmann, the Swiss chemist who, in 1943, accidentally found that he had discovered (five years earlier) the psychoactive molecule that came to be known as LSD. This was an unusual centennial in that the man being feted was very much in attendance. Entering his second century, Hofmann appeared in remarkably good shape, physically spry and mentally sharp, and he was able to take an active part in the festivities, which included a birthday ceremony followed by a three-day symposium. The symposium’s opening ceremony was on January 13, two days after Hofmann’s 100th birthday (he would live to be 102). Two thousand people packed the hall at the Basel Congress Center, rising to applaud as a stooped stick of a man in a dark suit and a necktie, barely five feet tall, slowly crossed the stage and took his seat. Two hundred journalist...

Three major events which changes the course of psychedelics in human history

“Mysticism,” he likes to say, “is the antidote to fundamentalism.”

important saying

“I was lying on my back underneath a ficus tree,” he recalls. “I knew it was going to be a strong experience. And the point came where the little I still was just started slipping away. I lost all awareness of being on the floor in an apartment in Baltimore; I couldn’t tell if my eyes were opened or closed. What opened up before me was, for lack of a better word, a space, but not our ordinary concept of space, just the pure awareness of a realm without form and void of content. And into that realm came a celestial entity, which was the emergence of the physical world. It was like the big bang, but without the boom or the blinding light. It was the birth of the physical universe. In one sense it was dramatic—maybe the most important thing that ever occurred in the history of the world—yet it just sort of happened.” I asked him where he was in all this. “I was a diffusely located observer. I was coextensive with this emergence.” Here I let him know he was losing me. Long pause. “I’m hesitating because the words are an awkward fit; words seem too constraining.” Ineffability is of course a hallmark of the mystical experience. “The awareness transcends any particular sensory modality,” he explained, unhelpfully. Was it scary? “There was no terror, only fascination and awe.” Pause. “Um, maybe a little fear.” From here on, Jesse watched (or whatever you call it) the birth of … everything, in the unfolding of an epic sequence beginning with the appearance of cosmic dust leading to...

LSD experience of a monk named - Jesse

the Council on Spiritual Practices (CSP), with the aim of “making direct experience of the sacred more available to more people.” The website downplays the organization’s interest in promoting entheogens—Bob Jesse’s preferred term for psychedelics—but does describe its mission in suggestive terms: “to identify and develop approaches to primary religious experience that can be used safely and effectively.” The website (csp.org)

council on pstchedelic research - csp.org

We’ve got five crayons when we need fifty thousand different shades.”

note

“There is so much authority that comes out of the primary mystical experience that it can be threatening to existing hierarchical structures.”

“The visual I had was from the 1800s and I was up on this stage. Two people next to me were slipping a noose around my neck while a crowd of people watched, cheering for my death. I felt drenched with guilt, just terrified. I was in a hell realm. And I remember Bill asking, ‘What’s going on?’ “ ‘I’m experiencing a lot of guilt.’ Bill replied, ‘That’s a very common human experience,’ and with that, the whole image of being hanged pixilated and then just disappeared, to be replaced by this tremendous sensation of freedom and interconnectedness. This was huge for me. I saw that if I can name and admit a feeling, confess it to someone, it would let go. A little older and wiser, now I can do this for myself.”

Early on I began to perceive that the effects of the drug respond strikingly to my own subjective determination. If, in response to the swelling intensity of the whole experience, I began to tense up with anxiety, the whole scene appears to tighten in some way. But if I then consciously remind myself to relax, to let myself go into the experience, the effect is dramatic. The space in which I seem to find myself, already enormous, suddenly yawns open even further and the shapes that undulate before my eyes appear to explode with new and even more extravagant patterns. Over and over again I had the overwhelming sense of infinity being multiplied by another infinity. I joked to my wife as she drove me home that I felt as if I had been repeatedly sucked into the asshole of God.

banality.

Karin Sokel, a life coach and energy healer in her fifties, described an experience “that changed everything and opened me profoundly.”

“openness to experience.” One of the five traits

world:

A month before our breakfast, Griffiths had received the Eddy Award from the College on Problems of Drug Dependence, perhaps the most prestigious lifetime achievement prize in the field.

“The true method of knowledge is experiment.”

Quote

This fact can be interpreted in two completely different ways. On the first interpretation, the mind-altering power of psilocybin argues for a firmly materialist understanding of consciousness and spirituality, because the changes observed in the mind can be traced directly to the presence of a chemical—psilocybin. What is more material than a chemical? One could reasonably conclude from the action of psychedelics that the gods are nothing more than chemically induced figments of the hominid imagination. Yet, surprisingly, most of the people who have had these experiences don’t see the matter that way at all. Even the most secular among them come away from their journeys convinced there exists something that transcends a material understanding of reality: some sort of a “Beyond.” It’s not that they deny a naturalistic basis for this revelation; they just interpret it differently.

There was never any doubt who could best help me on this quest, assuming he was willing. Paul Stamets, a mycologist from Washington State who literally wrote the book on the genus Psilocybe,fn2 in the form of the authoritative 1996 field guide Psilocybin Mushrooms of the World. Stamets has himself “published”—that is, identified and described in a peer-reviewed journal—four new species of Psilocybe, including azurescens, named for his son Azureusfn3 and the most potent species yet known. But while Stamets is one of the country’s most respected mycologists, he works entirely outside the academy, has no graduate degree, funds most of his own research,fn4 and holds views of the role of fungi in nature that are well outside the scientific mainstream and that, he will gladly tell you, owe to insights granted to him by the mushrooms themselves, in the course of both close study and regular ingestion.

First discovrer of mushrooms

Amadou is flammable and in ancient times was used to start and transport fires. Ötzi, the five-thousand-year-old “Ice Man” found mummified in an alpine glacier in 1991, was carrying a pouch in which he had a piece of amadou. Because of its antimicrobial properties, Fomes fomentarius was also used to dress wounds and preserve food. Stamets is so deep into the world of fungi there’s frequently one perched on top of his head.

Amadou mushroom

Stamets won a patent for a “mycopesticide”—a mutant mycelium from a species of Cordyceps that, after being eaten by carpenter ants, colonizes their bodies and kills them, but not before chemically inducing the ant to climb to the highest point in its environment and then bursting a mushroom from the top of its head that releases its spores to the wind.

Ant killer mushroom

(The biggest organism on earth is not a whale or a tree but a mushroom—a honey fungus in Oregon that is 2.4 miles wide.)

not?”

Stoned Ape Theory, first presented by Roland Fischer and then popularized/restated by Terence McKenna, is probably true—[ingestion of psilocybin] causing a rapid development of the hominid brain for analytical thinking and societal bonding. Did you know that 23 primates (including humans) consume mushrooms and know how to distinguish ‘good’ from ‘bad’?” I did not. But the brief, elliptical

Stoned ape theory

One spring afternoon toward the end of his freshman year, walking alone along the wooded ridgeline above campus, Stamets ate a whole bag of mushrooms, perhaps ten grams, thinking that was a proper dose. (Four grams is a lot.) As the psilocybin was coming on, Stamets spied a particularly beautiful oak tree and decided he would climb it. “As I’m climbing the tree, I’m literally getting higher as I’m climbing higher.” Just then the sky begins to darken, and a thunderstorm lights up the horizon. The wind surges as the storm approaches, and the tree begins to sway. “I’m getting vertigo but I can’t climb down, I’m too high, so I just wrapped my arms around the tree and held on, hugging it tightly. The tree became the axis mundi, rooting me to the earth. ‘This is the tree of life,’ I thought; it was expanding into the sky and connecting me to the universe. And then it hits me: I’m going to be struck by lightning! Every few seconds there’s another strike, here, then there, all around me. On the verge of enlightenment, I’m going to be electrocuted. This is my destiny! The whole time, I’m being washed by warm rains. I am crying now, there is liquid everywhere, but I also feel one with the universe. “And then I say to myself, what are my issues if I survive this? Paul, I said, you’re not stupid, but stuttering is holding you back. You can’t look women in the eyes. What should I do? Stop stuttering now—that became my mantra. Stop stuttering now, I said it over and over and over. “The ...

Stamets first experience with mushrooms

Psilocybes gave our hominid ancestors “access to realms of supernatural power,” “catalyzed the emergence of human self-reflection,” and “brought us out of the animal mind and into the world of articulated speech and imagination.” This last hypothesis about the invention of language turns on the concept of synesthesia, the conflation of the senses that psychedelics are known to induce: under the influence of psilocybin, numbers can take on colors, colors attach to sounds, and so on. Language, he contends, represents a special case of synesthesia, in which otherwise meaningless sounds become linked to concepts. Hence, the stoned ape: by giving us the gifts of language and self-reflection psilocybin mushrooms made us who we are, transforming our primate ancestors into Homo sapiens.

Explanation of the stone spe theory

stormy.

Once we register on our retinas the visual pattern of the object we’re searching for, it’s much more likely to pop out of the visual field. (In fact the technical name for this phenomenon is “the pop-out effect.”)

Pop out effect

Eaten by whom, or what? And why? Beug says that many animals are known to eat psilocybin mushrooms, including horses, cattle, and dogs. Some, like cows, appear unaffected, but many animals appear to enjoy an occasional change in consciousness too. Beug is in charge of gathering mushroom-poisoning reports for the North American Mycological Association and over the years has seen accounts of horses tripping in their paddocks and dogs that “zero in on Psilocybes and appear to be hallucinating.” Several primate species (aside from our own) are also known to enjoy psychedelic mushrooms. Presumably animals with a taste for altered states of consciousness have helped spread psilocybin far and wide. “The strains of a species that produced more rather than less psilocybin and psilocin would tend to be favored and so gradually become more widespread.” Eaten in small doses, psychedelic mushrooms might well increase fitness in animals, by increasing sensory acuity and possibly focus as well. A 2015 review article in the Journal of Ethnopharmacology reported that several tribes around the world feed psychoactive plants to their dogs in order to improve

Effect of psylocybin on animals

“Plants and mushrooms have intelligence, and they want us to take care of the environment, and so they communicate that to us in a way we can understand.” Why us? “We humans are the most populous bipedal organisms walking around, so some plants and fungi are especially interested in enlisting our support. I think they have a consciousness and are constantly trying to direct our evolution by speaking out to us biochemically. We just need to be better listeners.”

“I no longer feel that I am in this envelope of a human life called Paul Stamets. I am part of the stream of molecules that are flowing through nature. I am given a voice, given consciousness for a time, but I feel that I am part of this continuum of stardust into which I am born and to which I will return at the end of this life.” Stamets sounded very much like the volunteers I met at Hopkins who had had full-blown mystical experiences, people whose sense of themselves as individuals had been subsumed into a larger whole—a form of “unitive consciousness,” which, in Stamets’s case, had folded him into the web of nature, as its not so humble servant.

You are probably wondering what ever happened to the azzies Stamets and I found that weekend. Many months later, in the middle of a summer week spent in the house in New England where we used to live, a place freighted with memories, I ate them, with Judith. I crumbled two little mushrooms in each of two glasses and poured hot water over them to make a tea; Stamets had recommended that I “cook” the mushrooms to destroy the compounds that can upset the stomach. Judith and I each drank half a cup, ingesting both the liquid and the crumbles of mushroom. I suggested we take a walk on the dirt road near our house while we waited for the psilocybin to come on. However, after only about twenty minutes or so, Judith reported she was “feeling things,” none of them pleasant. She didn’t want to be walking anymore, she said, but now we were at least a mile from home. She told me her mind and her body seemed to be drifting apart and then that her mind had flown out of her head and up into the trees, like a bird or insect. “I need to get home and feel safe,” she said, now with some urgency. I tried to reassure her as we abruptly turned around and picked up our pace. It was hot and the air was thick with humidity. She said, “I really don’t want to run into anybody.” I assured her we wouldn’t. I still felt more or less myself, but it may be that Judith’s distress was keeping me from feeling the mushrooms; somebody had to be ready to act normally if a neighbor happened to drive by and roll...

Author's (Michael pollen) experience on psylocybin -