How to Change Your Mind: The New Science of Psychedelics

by Michael Pollan

Shortly after the article in Life was published, Wasson arranged to have some specimens of the Mexican mushrooms sent to Albert Hofmann in Switzerland for analysis. In 1958, Hofmann isolated and named the two psychoactive compounds, psilocybin and psilocin, and developed the synthetic version of psilocybin used in the current research. Hofmann also experimented with the mushrooms himself. “Thirty minutes after my taking the mushrooms,” he wrote, “the exterior world began to undergo a strange transformation. Everything assumed a Mexican character.” In 1962, Hofmann joined Wasson on one of his return trips to Huautla, during which the chemist gave María Sabina psilocybin in pill form. She took two of the pills and declared they did indeed contain the spirit of the mushroom.fn7 It didn’t take long for thousands of other people—including, eventually, celebrities such as Bob Dylan, John Lennon, and Mick Jagger—to find their way to Huautla and to María Sabina’s door.fn8