Of the three 2006 events that helped bring psychedelics out of their decades-long slumber, by far the most far-reaching in its impact was the publication that summer of the paper in Psychopharmacology described in the prologue—the one Bob Jesse e-mailed me at the time but that I didn’t bother to open. This event, too, had a distinctly spiritual cast, even though the experiment it reported was the work of a rigorous and highly regarded scientist: Roland Griffiths.