How to Change Your Mind: The New Science of Psychedelics

by Michael Pollan

Carl Jung once wrote that it is not the young but people in middle age who need to have an “experience of the numinous” to help them negotiate the second half of their lives.

Descriptions of such experiences always sound a little thin, at least when compared with the emotional impact people are trying to convey; for a life-transforming event, the words can seem paltry. When I mentioned this to Richards, he smiled. “You have to imagine a caveman transported into the middle of Manhattan. He sees buses, cell phones, skyscrapers, airplanes. Then zap him back to his cave. What does he say about the experience? ‘It was big, it was impressive, it was loud.’ He doesn’t have the vocabulary for ‘skyscraper,’ ‘elevator,’ ‘cell phone.’ Maybe he has an intuitive sense there was some sort of significance or order to the scene. But there are words we need that don’t yet exist. We’ve got five crayons when we need fifty thousand different shades.”

The flight instructions advise guides to use mantras like “Trust the trajectory” and “TLO—Trust, Let Go, Be Open.” Some guides like to quote John Lennon: “Turn off your mind, relax and float downstream.”

Volunteers are told they may experience the “death/transcendence of your ego or everyday self,” but this is “always followed by Rebirth/Return to the normative world of space & time.

Safest way to return to normal is to entrust self unconditionally to the emerging experiences.” Guides are instructed to remind volunteers they’ll never be left alone and not to worry about the body while journeying because the guides are there to keep an eye on it. If you feel as if you are “dying, melting, dissolving, exploding, going crazy etc.—go ahead.” Volunteers are quizzed: “If you see a door, what do y...

On the back was a quotation from William Blake that, it occurred to me later, neatly aligned the way of the scientist with that of the mystic: “The true method of knowledge is experiment.”

Stamets’s extract of turkey tail mushrooms (Trametes versicolor) has been shown to help cancer patients by stimulating their immune systems. (Stamets claims to have used it to help cure his mother’s stage 4 breast cancer.)

“If a gilled mushroom has purplish brown to black spores, and the flesh bruises bluish, the mushroom in question is very likely a psilocybin-producing species.”

Even if psilocybin in mushrooms began as “an accident of a metabolic pathway,” the fact that it wasn’t discarded during the course of the species’ evolution suggests it must have offered some benefit. “My best guess,” Beug says, “is that the mushrooms that produced the most psilocybin got selectively eaten and so their spores got more widely disseminated.”

“Everything is interaction and reciprocal,” wrote Humboldt, and that felt very much the case, and so, for the first time I can remember, did this: “I myself am identical with nature.”

One patient he treated in Vancouver, an alcoholic paralyzed by social anxiety, recalled Hubbard handing him a bouquet of roses during an LSD session: “He said, ‘Now hate them.’ They withered and the petals fell off, and I started to cry. Then he said, ‘Love them,’ and they came back brighter and even more spectacular than before. That meant a lot to me. I realized that you can make your relationships anything you want. The trouble I was having with people was coming from me.”

In half a dozen or so papers published in the early 1960s, the foundation’s researchers reported some provocative “results.” Seventy-eight percent of clients said the experience had increased their ability to love, 71 percent registered an increase in self-esteem, and 83 percent said that during their sessions they had glimpsed “a higher power, or ultimate reality.” Those who had such an experience were the ones who reported the most lasting benefits from their session.

Perhaps the most useful document on the website is the “Guidelines for Voyagers and Guides.”

you’ll have to concentrate to maintain the rhythm,

was reminded of the “flight instructions” that the guides employed at Johns Hopkins: instead of turning away from any monster that appears, move toward it, stand your ground, and demand to know, “What are you doing in my mind? What do you have to teach me?”

Terror seized me—and then, like one of those flimsy wooden houses erected on Bikini Atoll to be blown up in the nuclear tests, “I” was no more, blasted to a confetti cloud by an explosive force I could no longer locate in my head, because it had exploded that too, expanding to become all that there was. Whatever this was, it was not a hallucination. A hallucination implies a reality and a point of reference and an entity to have it. None of those things remained.

“Trust and let go” as a kind of mantra for his journey. Go wherever it takes you, he advised: “Climb staircases, open doors, explore paths, fly over landscapes.” But the most important advice for the journey he offered is always to move toward, rather than try to flee, anything truly threatening or monstrous you encounter—look it straight in the eyes. “Dig in your heels and ask, ‘What are you doing in my mind?’

Many of the volunteers I interviewed reported initial episodes of intense fear and anxiety before giving themselves up to the experience, as the guides encourage them to do. This is where the flight instructions come in. Their promise is that if you surrender to whatever happens (“trust, let go, and be open” or “relax and float downstream”), whatever at first might seem terrifying will soon morph into something else, and likely something pleasant, even blissful.

An individual human existence should be like a river: small at first, narrowly contained within its banks, and rushing passionately past rocks and over waterfalls. Gradually, the river grows wider, the banks recede, the waters flow more quietly, and in the end, without any visible break, they become merged in the sea, and painlessly lose their individual being.

“The biggest joy was on the way home,” he recalled. “In my cockpit window, every two minutes: the earth, the moon, the sun, and the whole panorama of the heavens. That was a powerful, overwhelming experience. “And suddenly I realized that the molecules of my body, and the molecules of my spacecraft, the molecules in the body of my partners, were prototyped, manufactured in some ancient generation of stars. [I felt] an overwhelming sense of oneness, of connectedness … It wasn’t ‘Them and Us,’ it was ‘That’s me! That’s all of it, it’s one thing.’ And it was accompanied by an ecstasy, a sense of ‘Oh my God, wow, yes’—an insight, an epiphany.”

‘the mind being an excellent servant but a terrible master.’

“The psychedelic journey may not give you what you want,” as more than one guide memorably warned me, “but it will give you what you need.”

Many of these were the kinds of things one might learn in the course of psychotherapy: insights into important relationships; the outlines of fears and desires ordinarily kept out of view; repressed memories and emotions; and, perhaps most interesting and useful, a new perspective on how one’s mind works.

This, I think, is the great value of exploring non-ordinary states of consciousness: the light they reflect back on the ordinary ones, which no longer seem quite so transparent or so ordinary.