How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence
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“How do I know if a mushroom is a psilocybin producing species or not?”
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“If a gilled mushroom has purplish brown to black spores, and the flesh bruises bluish, the mushroom in question is very likely a psilocybin-producing species.”
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the Stoned Ape Theory, first presented by Roland Fischer and then popularized/restated by Terence McKenna, is probably true—[ingestion of psilocybin] causing a rapid development of the hominid brain for analytical thinking and societal bonding. Did you know that 23 primates (including humans) consume mushrooms and know how to distinguish ‘good’ from ‘bad’?”
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the “placebo sacraments” of the Catholic Eucharist.
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Before 1965, when a moral panic erupted over LSD, Time-Life publications were enthusiastic boosters of psychedelics,
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each Indo-European people is by cultural inheritance either mycophobic (for example, the Anglo-Saxons, Celts, and Scandinavians) or mycophilic (the Russians, Catalans, and Slavs)
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In 1620, the Roman Catholic Church declared that the use of plants for divination was “an act of superstition condemned as opposed to the purity and integrity of our Holy Catholic Faith.”
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by 1955 many Mazatecs had become devout Catholics, and they now used mushrooms not for worship but for healing and divination—to locate missing people and important items.
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An exhibition on magic mushrooms soon followed at the American Museum of Natural History in New York.
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the mushroom itself that helped form precisely the kind of mind—endowed with the tools of language and fired by imagination—that could best advance its interests.
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article in the Journal of Ethnopharmacology reported that several tribes around the world feed psychoactive plants to their dogs in order to improve their hunting ability.
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So much of what Stamets has to say treads a perilously narrow ledge, perched between the autodidact’s soaring speculative flights and the stoned crank’s late night riffings that eventually send everyone in earshot off to bed.
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“Nature everywhere speaks to man in a voice” that is “familiar to his soul.”
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scientists (a word that wasn’t coined until 1834)
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The phrase “parallel play” popped into my mind, and so it would be for the rest of the afternoon.
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whatever it is that usually divides me from the world out there had begun to fall away.
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one’s usual sense of oneself as a subject observing objects in space—objects that have been thrown into relief and rendered discrete by the apparent void that surrounds them—gave way to a sense of being deep inside and fully implicated in this scene, one more being in relation to the myriad other beings and to the whole.
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when we mix our emotions with certain objects that then reflect those feelings back to us so that they appear to glisten with meaning. T. S. Eliot called these things and situations the “objective correlatives” of human emotion.
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italicized the prose of ordinary experience,
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Nature does in fact teem with subjectivities—call them spirits if you like—other than our own; it is only the human ego, with its imagined monopoly on subjectivity, that keeps us from recognizing them all, our kith and kin.
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Maybe to be in a garden and feel awe, or wonder, in the presence of an astonishing mystery, is nothing more than a recovery of a misplaced perspective, perhaps the child’s-eye view;
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to quote William James again, “forbid[s] a premature closing of our accounts with reality.”
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I was hardly alone in assuming that the Harvard Psilocybin Project—launched by Leary in the fall of 1960, immediately after his first life-changing experience with psilocybin in Mexico—represented the beginning of serious academic research into these substances or that Leary’s dismissal from Harvard in 1963 marked the end of that research. But in fact neither proposition is even remotely true.
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Beginning in the early fifties, psychedelics had been used to treat a whole host of conditions,” including addiction, depression, obsessive-compulsive disorder, schizophrenia, autism, and end-of-life anxiety.
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Hoping someone somewhere would hit upon a commercial application for its spookily powerful new compound, Sandoz offered to supply, free of charge, however much LSD any researcher requested.
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As the literary theorists would say, the psychedelic experience is highly “constructed.” If you are told you will have a spiritual experience, chances are pretty good that you will, and, likewise, if you are told the drug may drive you temporarily insane, or acquaint you with the collective unconscious, or help you access “cosmic consciousness,” or revisit the trauma of your birth, you stand a good chance of having exactly that kind of experience.
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So did Aldous Huxley “make sense” of the modern psychedelic experience, or did he in some sense invent it?
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When “set” and “setting” play such a big role in the patient’s experience, how can you hope to isolate a single variable or design a therapeutic application?
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beginning around 1950, shortly after LSD was made available to researchers, the compound was known as a psychotomimetic, which is to say, a mind drug that mimicked psychoses.
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“a tantalizing sense of portentousness.”
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the molecular structure of mescaline closely resembled that of adrenaline.
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The fact that such a vanishingly small number of LSD molecules could exert such a profound effect on the mind was an important clue that a system of neurotransmitters with dedicated receptors might play a role in organizing our mental experience. This insight eventually led to the discovery of serotonin and the class of antidepressants known as SSRIs.
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The emphasis on what subjects felt represented a major break with the prevailing ideas of behaviorism in psychology,
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Hoping to isolate the effects of the drug from all other variables, clinicians administered LSD to alcoholics in neutral rooms and under instructions not to engage with them during their trips, except to administer an extensive questionnaire. The volunteers were then put in constraints or blindfolded, or both. Not surprisingly, the results failed to match those obtained by Osmond and Hoffer.
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Bill W. thought there might be a place for LSD therapy in AA, but his colleagues on the board of the fellowship strongly disagreed,
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psychotomimetic paradigm was replaced not by one but by two distinct new theoretical models: the psycholytic and, later, the psychedelic model.
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“psycholytic” means “mind loosening,” which is what LSD and psilocybin seem to do—at least at low doses.
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the most famous of these patients was Cary Grant, who gave an interview in 1959 to the syndicated gossip columnist Joe Hyams extolling the benefits of LSD therapy. Grant had more than sixty sessions and by the end declared himself “born again.”
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takes psychotherapy perilously close to the world of shamanism and faith healing, a distinctly uncomfortable place for a scientist to be.
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great writers stamp the world with their minds, and the psychedelic experience will forevermore bear Huxley’s indelible imprint.
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“People will think they are going mad, when in fact they are beginning, when they take it, to go sane.”
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To fathom Hell or go angelic Just take a pinch of psychedelic.
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Hubbard’s greatest contribution to modern psychedelic therapy was to introduce the tried-and-true tools of shamanism, or at least a Westernized version of it.
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For Hubbard, psychedelic therapy was a form of philanthropy, and he drained his fortune advancing the cause.
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desire to treat the whole of society. (This aspiration seems eventually to infect everyone who works with psychedelics,
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Seventy-eight percent of clients said the experience had increased their ability to love, 71 percent registered an increase in self-esteem, and 83 percent said that during their sessions they had glimpsed “a higher power, or ultimate reality.”
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“much less judgmental, much less rigid, more open, and less defended.”
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“everyone in that community”—referring to the Bay Area tech crowd in the 1960s and early 1970s, as well as the people in and around Stewart Brand’s Whole Earth Network—“had taken Hubbard LSD.”
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“problem solving in engineering always involves irreducible complexity. You’re always balancing complex variables you can never get perfect, so you’re desperately searching to find patterns. LSD shows you patterns. “I have no doubt that all that Hubbard LSD all of us had taken had a big effect on the birth of Silicon Valley.”
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How much does the idea of cyberspace, an immaterial realm where one can construct a new identity and merge with a community of virtual others, owe to an imagination shaped by the experience of psychedelics? Or for that matter virtual reality?* The whole notion of cybernetics, the idea that material reality can be translated into bits of information, may also owe something to the experience of LSD, with its power to collapse matter into spirit.