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July 22 - December 25, 2018
bold escape from a California prison, with the help of the Weathermen, the revolutionary group.
rise of the placebo-controlled double-blind trial as the “gold standard” for testing drugs in the wake of the thalidomide scandal, a standard difficult for psychedelic research to meet.
It remains something of a mystery why this large psychedelic research program was allowed to continue—as it did until 1976—when dozens of others were being closed down. Some researchers who weren’t so fortunate speculate that Spring Grove might have been making psychedelic therapy available to powerful people in Washington who recognized its value or hoped to learn from the research or perhaps wanted to retain their own access to the drugs.
Some are religious professionals—rabbis and ministers of various denominations; a few call themselves shamans; one described himself as a druid.
syncretism
Members of this community tend to be more spiritual than religious in any formal sense, focused on the common core of mysticism or “cosmic consciousness” that they believe lies behind all the different religious traditions. So what appeared to me as a bunch of conflicting symbols of divinity are in fact different means of expressing or interpreting the same underlying spiritual reality, “the perennial philosophy” that Aldous Huxley held to undergird all religions and to which psychedelics supposedly can offer direct access.
“the first New Age graduate school”—the California Institute of Integral Studies. Founded in 1968, the institute specializes in “transpersonal psychology,” a school of therapy with a strong spiritual orientation rooted in the work of Carl Jung and Abraham Maslow as well as the “wisdom traditions” of the East and the West, including Native American healing and South American shamanism.
In 2016, the institute began offering the nation’s first certificate program in psychedelic therapy.
These days he works with a lot of young people in the tech world. “I’m the dangerous virus of Silicon Valley. They come to me wondering, ‘What am I doing here, chasing the golden carrot in the golden cage?’ Many of them go on to do something more meaningful with their lives.
“You may not get what you want,” he told me, “but you’ll get what you need.” I gulped mentally.
working with a man my age who became convinced during his psilocybin journey he was having a heart attack. “‘I’m dying,’ he said, ‘call 911! I feel it, my heart!’ I told him to surrender to the dying. That Saint Francis said that in dying you gain eternal life. When you realize death is just another experience, there’s nothing more to worry about.”
Andrei mentioned that an aspiring guide he was training had “once asked me, ‘What do you do if someone dies?’” I don’t know what I expected him to say, but Andrei’s reply, delivered with one of his most matter-of-fact shrugs, was not it. “You bury him with all the other dead people.” I told Andrei I would be in touch.
ONE NOTABLE DIFFERENCE about doing psychedelics at sixty, as opposed to when you’re eighteen or twenty, is that at sixty you’re more likely to have a cardiologist you might want to consult in advance of your trip.
Sometimes called an empathogen, MDMA lowers psychological defenses and helps to swiftly build a bond between patient and therapist. (Leo Zeff was one of the first therapists to use MDMA in the 1970s, after the compound was popularized by his friend the legendary Bay Area chemist Sasha Shulgin
Guides told me MDMA was a good way to “break the ice” and establish trust before the psychedelic journey. (One said, “It condenses years of psychotherapy into an afternoon.”)
with a dense understory of manzanitas, their smooth bark the color of fresh blood.
He now added Holotropic Breathwork to his bodywork practice.
surfeit of compassion
“The mushroom teacher helps us to see who we really are,” Mary said, “brings us back to our soul’s purpose for being here in this lifetime.”
We settled on the second of Bach’s unaccompanied cello suites, performed by Yo-Yo Ma. The suite in D minor
Losing myself in this music was a kind of practice for that—for losing myself, period. Having let go of the rope of self and slipped into the warm waters of this worldly beauty—Bach’s sublime music, I mean, and Yo-Yo Ma’s bow caressing those four strings suspended over that envelope of air—I felt as though I’d passed beyond the reach of suffering and regret.
no sleeping monsters had awakened in my unconscious and turned on me. This was a deep fear that went back several decades, to a terrifying moment in a hotel room in Seattle when, alone and having smoked too much cannabis, I had had to marshal every last ounce of will to keep myself from doing something deeply crazy and irrevocable.
twenty-four hours later, my old ego was back in uniform and on patrol, so what long-term good was that beguiling glimpse of a loftier perspective? Mary suggested that having had a taste of a different, less defended way to be, I might learn, through practice, to relax the ego’s trigger-happy command of my reactions to people and events.
“Now you have had an experience of another way to react—or not react. That can be cultivated.” Meditation, she suggested, was one way to do that.
we get to experience an extreme version of Keats’s “negative capability”—the ability to exist amid doubts and mysteries without reflexively reaching for certainty.
5-MeO-DMT (or, The Toad) Yes, “the toad,” or to be more precise, the smoked venom of the Sonoran Desert toad (Incilius alvarius),
It is so obscure, in fact, that the federal government did not list 5-MeO-DMT as a controlled substance until 2011.
Rocío is from the state of Sonora, in northern Mexico, where she collects the toads and milks their venom; she administers the medicine to people both in Mexico, where its legal status is gray, and in the United States, where it isn’t. (It doesn’t appear to be on the official radar, however.)
Rocío worked in a clinic in Mexico that treated drug addicts with a combination of iboga, a psychedelic plant from Africa, and 5-MeO-DMT—apparently with striking rates of success.
In recent years, she’s become the Johnny Appleseed of toad, traveling all over North America with her capsules of cry...
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“They’re not very hard to catch,” she told me. “They freeze in the beam of light so you can just grab them.” The toads, which are warty, sand colored, and roughly the size of a man’s hand, have a large gland on each side of their necks, and smaller ones on their legs. “You gently squeeze the gland while holding a mirror in front of it to catch the spray.” The toad is apparently none the worse for being milked. Overnight, the venom dries on the glass, turning into flaky crystals the color of brown sugar.
wasn’t there also a great virtue and psychic benefit in simply being? In contemplation rather than action? I decided I needed to practice being with stillness, being with other people as I find them (imperfect), and being with my own unimproved self.
It lacked the beginning, middle, and end that all my previous trips had had and that we rely on to make sense of experience.
All three molecules are tryptamines.
they typically act as signaling molecules between cells. The most famous tryptamine in the human body is the neurotransmitter serotonin,
substantial representation in the digestive tract.
The group of tryptamines we call “the classic psychedelics” have a strong affinity with one particular type of serotonin receptor, called the 5-HT2A. These receptors are found in large numbers in the human cortex,
Curiously, LSD has an even stronger affinity with the 5-HT2A receptor—is “stickier”—than serotonin itself, making this an instance where the simulacrum is more convincing,
he would use psychedelic drugs and modern brain-imaging technologies to build a foundation of hard science beneath the edifice of psychoanalysis.
“Freud said dreams were the royal road to the unconscious,” he reminded me. “Psychedelics could turn out to be the superhighway.”
He likes to quote Grof’s grand claim that what the telescope was for astronomy, or the microscope for biology,
trepanation.

