Mentally, long-term sleep deprivation over many days elevates suicidal thoughts and suicide attempts, both of which occur at vastly higher rates in detained prisoners relative to the general population. Inadequate sleep further cultivates the disabling and non-transient conditions of depression and anxiety. Physically, prolonged sleep deprivation increases the likelihood of a cardiovascular event, such as a heart attack or stroke, weakens the immune system in ways that encourage cancer and infection, and renders genitals infertile.