benefit of calorie restriction is that it reduces levels of IGF-1 (insulin-like growth factor 1) in the body. IGF-1 is a protein that plays a significant role in the aging process; it seems that one of the reasons humans and animals age is an excess of this protein in their blood.2 Whether calorie restriction will extend lifespan in humans is not yet known, but data increasingly indicate that moderate calorie restriction with adequate nutrition has a powerful protective effect against obesity, type 2 diabetes, inflammation, hypertension, and cardiovascular disease and reduces metabolic risk
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