The following are my guidelines for the prevention and treatment of cardiovascular disease: PREVENTION Follow the Longevity Diet (chapter 4) and the exercise guidelines (chapter 5). Undergo periodic fasting-mimicking diets. For very healthy individuals with no cardiovascular-disease risk factors, we recommend FMD once every six months. For those overweight with multiple risk factors for cardiovascular diseases, including a family history of heart disease or stroke, we recommend FMD once a month until normal weight is achieved, then it can be reduced according to the guidelines in chapter