In our cancer studies with mice, we had determined that four major changes in the blood need to occur to show that the mouse had entered a protected state as a result of fasting: (1) lower levels of the growth factor IGF-1; (2) lower levels of glucose; (3) higher levels of ketone bodies, the by-product of fat breakdown; and (4) higher levels of a growth factor inhibitor (IGFBP1). To achieve these results (i.e., to mimic fasting), we fine-tuned a diet low in proteins and sugars and rich in healthy fats. We took advantage of many additional nutritechnologies developed in my lab to ensure proper
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