Of the many hormones at play when we are stressed, two are particularly important: cortisol and dehydroepiandrosterone (DHEA). While neither is categorically “good” or “bad” and both are necessary, chronically elevated cortisol levels are associated with lingering inflammation, impaired immune function, and depression. By contrast, DHEA has been linked to a reduced risk of anxiety, depression, heart disease, neurodegeneration, and a range of other diseases and conditions.