The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

by Dale E. Bredesen

who carry a gene variant (allele) called ApoE4 (ApoE is short for apolipoprotein E; an apolipoprotein is a protein that carries lipids—i.e., fats). ApoE4 is the strongest known genetic risk factor* for Alzheimer’s disease.

“Everyone knows a cancer survivor; no one knows an Alzheimer’s survivor.”

Alzheimer’s disease does not arise from the brain failing to function as it evolved to.

Inflammation (from infection, diet, or other causes) Decline and shortage of supportive nutrients, hormones, and other brain-supporting molecules Toxic substances such as metals or biotoxins (poisons produced by microbes such as molds)

cognitive decline is largely a matter of three fundamental threats to our brain: inflammation; a shortage of brain-boosting nutrients, hormones, and other cognition-supporting molecules; and toxic exposure.

after insulin molecules do their job and lower the glucose, the body must degrade the insulin in order to prevent dropping the blood glucose too low. It does this via an enzyme called insulin-degrading enzyme (IDE). Guess what else IDE degrades? Amyloid, the protein fragment in the sticky, synapse-destroying plaques in Alzheimer’s disease.