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But those surviving the disease developed immunity, and a small degree of immunity could be passed down through parents. Smallpox is thought to have originated with farm animals—especially cattle, but also horses and sheep—and then crossed species to infect humans. Europeans had a great deal of contact with those animals, whereas the Inca and Aztec people had none.
Get Well Soon: History's Worst Plagues and the Heroes Who Fought Them
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