I have been shocked by how much supplementation some of my autoimmune patients need to get their vitamin D blood levels up to what I consider normal, which is 70 to 105 ng/ml for serum 25-hydroxyvitamin D, the active form of vitamin D in your body. Because I measure vitamin D levels every three months, I can be aggressive with replacement, but if you are just beginning this program, please add just 5000 IUs of vitamin D3 daily. For autoimmune disease, start with 10,000 a day. In the last seventeen years, I have yet to see a case of vitamin D toxicity. In fact, I doubt that it exists.