Unfortunately, when the stress response is triggered repeatedly (by the constant hectic pace of modern life, by a demanding boss, or by overly stressful workouts), your stress response mechanisms eventually wear out, and you produce lower-than-normal levels of cortisol and other hormones critical to many aspects of everyday health. Thyroid hormones and testosterone also become dysregulated from prolonged stress, resulting in fatigue, loss of lean muscle tissue, a suppressed immune system, and the general condition best described as burnout.