How does this apply to insulin and obesity? Consider the experiment described earlier that used constant infusions of insulin. Even healthy young men quickly developed insulin resistance. But the levels of insulin administered were normal. What changed? The periodic release. Normally, insulin is released in bursts, which prevents the development of insulin resistance. In the experimental condition, the constant bombardment of insulin led the body to down regulate its receptors and develop insulin resistance. Over time, insulin resistance induces the body to produce even more insulin to
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