CALORIC REDUCTION: EXTREME EXPERIMENTS, UNEXPECTED RESULTS EXPERIMENTALLY, IT’S EASY to study caloric reduction. We take some people, give them less to eat, watch them lose weight and live happily ever after. Bam. Case closed. Call the Nobel committee: Eat Less, Move More is the cure for obesity, and caloric reduction truly is the best way to lose weight. Luckily for us, such studies have already been done.