ANTIBIOTIC RESISTANCE LET’S START WITH antibiotic resistance. When new antibiotics are introduced, they kill virtually all the bacteria they’re designed to kill. Over time, some bacteria develop the ability to survive high doses of these antibiotics. They’ve become drug-resistant “superbugs,” and infections from them are difficult to treat and can sometimes lead to death. Superbug infections are a large and growing problem in many urban hospitals worldwide. All antibiotics have begun to lose their effectiveness due to resistance.