HOW DOES INSULIN resistance produce obesity? We know that the hypothalamic area of the brain controls the body set weight and that insulin plays a key role in resetting the body set weight up or down. As insulin resistance develops, does it develop in all the cells in the body, including the brain? If all cells are insulin resistant, then high levels of it should not increase the body set weight. However, all the cells in the body are not equally resistant. Insulin resistance is compartmentalized.
