Fructose was previously considered a benign sweetener because of its low glycemic index. Fructose is found naturally in fruits, and is the sweetest naturally occurring carbohydrate. What could be wrong with that? The problem, as often is the case, is a matter of scale. Natural fruit consumption contributed only small amounts of fructose to our diet, in the range of 15 to 20 grams per day. Things began to change with the development of high-fructose corn syrup.