Excessive fructose puts significant pressure on the liver since other organs cannot help. It is the difference between pressing down with a hammer and pressing down with a needlepoint: much less pressure is needed if it is all directed onto a single point. At the liver, fructose is rapidly metabolized into glucose, lactose and glycogen. The body handles excess glucose consumption through several well-defined metabolic pathways, such as glycogen storage and de novo lipogenesis (creation of new fat). No such system is present for fructose. The more you eat, the more you metabolize. The bottom
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