It may sound trite to say that confusion is the most confusing syndrome in medicine, but it is. A confused person behaves in a way so foreign to common experience that it can be unnerving, even for professionals. It is an alternate state of being. Portrayals of confusion in popular culture—the town drunk, for example—may look funny, but in the case of a truly confused person, the sight of someone who can’t find his own mind can be overwhelming.