Of all the things that can make finding something difficult—false positives, false negatives, moving targets, incorrect search areas, lack of resources, the vagaries of chance, the general immensity of the world—one of the thorniest is this: sometimes, we don’t really know what we’re looking for. Maybe you are trying to find the perfect wedding gift for that notorious Friend Who Has Everything. Maybe you are trying to find someone to date in order to someday have a wedding of your own. Maybe you are trying to find a drug that will impede the development of plaque in the brain. In all of these
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