Antidepressant Trial Failed To Mention Numerous Suicide Attempts

Health and Medicine





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A controversial study of antidepressants for teenagers failed to report numerous suicidal incidents and privileged investigator assessments over how the participants felt. Credit: Mykola Ivashchenko/Shutterstock

 

Clinical notes from a trial of the antidepressant paroxetine, reported as finding it to be both safe and effective for adolescents, in fact showed the opposite, researchers have claimed. The largest re-examination of clinical data from a high profile trial has found a terrifyingly high rate of suicidal behavior that failed to be reported in the controversial study. The revelation could influence the prescription of similar drugs and will add to pressure to change the conduct of clinical drug trials, particularly for antidepressants.