Nature publishes paper on the edge of evolution, Part 2

Nature has recently published an interesting paper which places severe limits on Darwinian evolution. The manuscript, from the laboratory of Joseph Thornton at the University of Oregon, is entitled "An epistatic ratchet constrains the direction of glucocorticoid receptor evolution". ( http://tinyurl.com/yeq2cy8 ) The work is interpreted by its authors within a standard Darwinian framework, but the results line up very well with arguments I made in The Edge of Evolution. (