Lab-Grown Vaginas

A team of scientists has successfully implanted lady-parts cultivated from stem cells into four women born without them:

The women, who were between 13 and 18 at the time of the surgery, were all born with a rare genetic condition called Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) — a condition that causes about one in 4,500 girls to be born with either an underdeveloped or absent vagina and uterus. The traditional treatment for women with MRKH involves reconstructive surgery or painful dilation procedures. These interventions can be quite traumatic — they have a complication rate of 75 percent in pediatric patients — so researchers wanted to find a way to avoid them altogether. That’s why they set out to engineer vaginas, described in a study published in The Lancet today, that would be compatible with each patient.

How they did it:

The vaginal organs were engineered with muscle and epithelial cells from biopsies of the women’s genitals. The cells were taken from the tissues, grown, and put into a biodegradable material that is then formed into the shape of a vagina and fit to each patient. When the vagina is placed into the bodies of the patients, the nerves and blood vessels help expand it into tissue. The biodegradable material is absorbed into the body, and cells form a new structure and organ.

The cultured cells were grown on scaffolds like this one:

Jason Koebler celebrates this triumph for medical science:

Besides how awesome this obviously is for those four women, it represents a huge win for regenerative medicine and a look at what could be the future of transplantation. Researchers in the United Kingdom are working on making lab-grown noses, ears, and blood vessels, but so far, implanting them back into humans has proven difficult. With the success of this experiment, Anthony Atala, who worked on the transplantation team, says things like this could one be the norm for people who are born with disorders or otherwise need a new organ.

It’s certainly an improvement over the mouse method: