Advice on visiting Tokyo for first time?

Later this year I’ll be visiting Tokyo for the first time. I’ve always wanted to go to Japan and finally I’ve lined things up for it to happen. Yay.

In doing research and reading up on the city I find, for the first time, I’m overwhelmed. I’m very well traveled, love cities and public transportation, but I’m struggling to figure out what neighborhood to stay in, as well as what to expect in terms of getting around without speaking any Japanese. I’m considering hiring a guide for the first day to accelerate getting over the basics of getting around and how things work.

I don’t need to stay in the center of nightlife, but do love being able to walk to interesting neighborhoods, streets, and restaurants.

If you’re a local or you’ve been there recently, any advice welcome.  Thanks.