Summary of Supportive Science Regarding Thimerosal Removal

Thimerosal is well‐
known to sensitize IP3 receptors via its induction of oxidative stress, resulting in enhanced
release of intracellular calcium with distinctive consequences for various cell types.
Dysregulated calcium signaling in T cells and other immune cells can result in autoimmunity,
while hyperpolarization of vascular smooth muscle cells secondary to the stimulation of
calcium‐activated potassium channels can result in increased vascular permeability and arterial
relaxation. We propose that ITPKC susceptibility in KS is related to its synergy with
environmental triggers, such as thimerosal, which alter calcium homeostasis and promote
oxidative stress.