A man with virtually no serotonin or dopamine

[image error]Neuroskeptic covers a fascinating case of a man born with a genetic mutation meaning he had a severe lifelong deficiency of both serotonin and dopamine.

The case report concerns a gentleman with sepiapterin reductase deficiency, a genetic condition which prevents the production of the enzyme sepiapterin reductase which is essential in the synthesis of both dopamine and serotonin.

The most widely recognised symptoms of the condition, linked to the deficiency in dopamine which has an important...