when to send off a manuscript

I do not send out manuscripts unless I have gone over and over them. I have readers go over them. I let them sit for several months and then reread them. I have a phobia about editors discovering some random paragraph or typos all over or that a character's name changes in the middle of the text or that the ending makes no sense at all. Probably I have this phobia because I have had all of these things happen to me when I get comments back.

So when people ask me how to know when a manuscri...