Aspartame Approved by FDA Dir. Who Died 19 Years Later From Cancer Aspartame Causes

http://www.boston.com/bostonglobe/obituaries/articles/2010/03/02/arthur_hayes_jr_76_fda_boss_calmed_fears_during_tylenol_case/
Arthur Hayes Jr., 76; FDA boss died of Leukemia 2/11/10 almost 19 years after approving Aspartame, which caused Leukemia in scientific tests published in  ARTHUR HAYES JR.By Dennis HevesiNew York Times / March 2, 2010NEW YORK - Arthur Hayes Jr., who while leading the Food and Drug Administration during the Reagan administration helped calm consumer fears after a Tylenol poisoning case and, amid some controversy, approved the use of the artificial sweetener found in Equal and NutraSweet, died Feb. 11 in Danbury, Conn. He was 76 and lived in Oxford, Conn.

The cause was leukemia, said his son, Arthur III.

Dr. Hayes, a pharmacological researcher, was appointed commissioner of the FDA by President Reagan in April 1981. He served until August 1983.

The biggest crisis faced by the agency under Dr. Hayes was a nationwide alarm in 1982 caused by the deaths of seven people in the Chicago area who had taken Extra-Strength Tylenol capsules laced with cyanide. The case remains unsolved. Under Dr. Hayes's leadership, the government and the drug industry responded by developing the first federal regulations requiring tamper-resistant packaging for all over-the-counter drugs.

In 1981, Dr. Hayes granted approval for the use of the sugar substitute aspartame in dry foods and as a tabletop sweetener. Research had found that aspartame was associated with high rates of cancers in rats that had been given large doses, starting at what would be the equivalent of four to five 20-ounce bottles of diet soda a day for a 150-pound person.

Dr. Hayes insisted that there was no need for people to avoid the sweetener.

Research done after Dr. Hayes's time as commissioner indicated that aspartame can sometimes cause incapacitating headaches and even seizures.

Arthur Hull Hayes Jr. was born in Highland Park, Mich., one of four children of Arthur and Florence Gruber Hayes. His father was president of CBS Radio.

Dr. Hayes received his bachelor's degree in philosophy in 1955 from Santa Clara University and then went to Oxford as a Rhodes scholar, earning a degree in philosophy, politics, and economics in 1957. He returned to the United States to study medicine and graduated from Cornell University Medical School in 1964. He served in the US Army Medical Corps from 1965 to 1967.

From 1967 to 1981, Dr. Hayes was an assistant professor of medicine and pharmacology at Cornell. He later became director of clinical pharmacology at the Pennsylvania State University medical school. After leaving the FDA, he was dean of New York Medical College and, in 1986, was named president of E.M. Pharmaceuticals.

© Copyright 2010 Globe Newspaper Company.



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Figure 1.

Effects of APM exposure on feed consumption, body weight, and survival. Mean daily feed consumption in males (A) and females (B). (C) Mean body weights in males (M) and females (F). Survival in males (D) and females (E). Arrows indicate the start of the experiment.

Figure 2.

Cumulative prevalence of death by age in female rats bearing hemolymphoreticular neoplasias. (A) Postnatal APM exposure. (B) Prenatal APM exposure. Arrows indicate the start of the experiment.

Table 1.

Incidence of malignant tumors in male Sprague-Dawley rats exposed to APM from fetal day 12 throughout the life span.

Table 2.

Incidence of malignant tumors in female Sprague-Dawley rats exposed to APM from fetal day 12 throughout the life span.

Table 3.

Comparison of the incidence of lymphomas/leukemias in female Sprague-Dawley rats beginning APM exposure from postnatal or prenatal life.

ResourcesFile for SSI DisabilityNewspaper Archive to 1690  Find Death Certificates Elizabeth Anne (Lisa) Waller-HayesObituaryGuest Book3 entries"To Lisa's husband, children and the Hayes family- I was..."- Kathleen OremThe Guest Book is expired.Restore the Guest Book
WALLER-HAYES Elizabeth Anne (Lisa) Waller-Hayes, ('89), born on June 13, 1964, died June 9, at her home in Overveen, The Netherlands, after a courageous battle with pancreatic cancer. An accomplished journalist, she worked for Health Action International, Medecines Sans Frontieres (Doctors Without Borders) and other international organizations devoted to health care and human rights, as a writer, editor, translator and communications strategy advisor. She was 45 years old. Her passion for social justice will live on in her work, and her love of the English language will be reflected in the Elizabeth Hayes and Family scholarships established in her name at the College of the Holy Cross and The Columbia University Graduate School of Journalism. The Lisa Waller-Hayes Foundation, was recently established in The Netherlands to promote research and provide services to patients and families struggling with pancreatic cancer. (www.lisawallerhayesfoundation.com) In addition to her husband of 16 years, Arnoud (Nout) Waller, Lisa is survived by her two children, Bastiaan, 12, and Isabel, 10 of the Netherlands; her mother, Barbara Hayes of Oxford; brother and sister-in-law, Arthur and Lisa J. Hayes of Westport; and sister and brother-in-law, Kathy and Robert Saracino of Oxford; Her father, Arthur Hull Hayes, Jr., MD, died in February of this year. A memorial service was held in The Netherlands on June 16. A Mass is planned at St. Thomas the Apostle Church in Oxford on Saturday, July 24, 2010 at 11 a.m.

Published in Connecticut Post on July 11, 2010Print  |  View Guest Book