AntiCancer Effects of Hydrogen Gas Inhalation

AntiCancer Effects of Hydrogen Gas Inhalation by Jeffrey Dach MD

Remission of Extensive Brain Mets with Inhalation of Hydrogen Gas

Case Number One: A 51-year-old female patient was presented to medical attention with left arm pain for a month. She was diagnosed with Non-Small Cell Lung Cancer (NSCLC) with multiple brain metastases. The patient was initially treated with Gefitinib and Osimertinib with no clinical response to these two Tyrosine Kinase Inhibitor drugs.

Note: Gefitinib, an oral tyrosine kinase inhibitor (TKI) against epidermal growth factor receptor (EGFR) was FDA approved in 2015 for metastatic non-small cell lung cancer (NSCLC) whose tumors have specific mutations in the gene for the epidermal growth factor receptor (EGFR). Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor.

Following this, the patient received 28 days of Whole Brain Radiotherapy (WBRT). One week after completing the radiation therapy, the patient worsened with severe headache, vomiting, confusion, and incontinence. At this time, follow up brain MRI scan showed explosive worsening of the metastatic brain lesions (see above header image). Above Header Image: after Whole Brain Radiotherapy with Explosive Progression of Metasatic Lesions Courtesy of Xu, Kecheng, et al. “Explosive Progression of Brain Metastases from Lung Adenocarcinoma after Radiotherapy and Significant Reversal after Inhalation of Hydrogen-Oxygen Gas: A Case Report.” Ann Med Case Rep. 2022;4(1):1032.

Following this, having exhausted all conventional treatments, there was nothing left to offer this patient. As a palliative measure, the patient was treated with hydrogen gas inhalation therapy, using a mixture of 66% Hydrogen gas and 34% Oxygen, 3 liters/min, 6 hours a day. Within a week, the patient’s condition started to improve. One month later the patient was markedly improved. Remarkably, a follow up brain MRI scan at this time showed almost complete clearing of the metastatic lesions.

Above Image: Follow Up MRI Scan of Brain  2 Months after starting Hydrogen Gas Inhalation. Almost All Metastatic Lesion Have Cleared. This was durable remission on later follow up. Courtesy of Xu, Kecheng, et al. “Explosive Progression of Brain Metastases from Lung Adenocarcinoma after Radiotherapy and Significant Reversal after Inhalation of Hydrogen-Oxygen Gas: A Case Report.” Ann Med Case Rep. 2022;4(1):1032.

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Case Number Two :

Above images: Remarkable MRI scan documentation of disappearance of brain metastatic lesions in a patient with small cell lung cancer after treatment with hydrogen gas inhalation.

Thanks and credit to Daniel Stanciu, PhD for bringing this case report to my attention. See above images before and after hydrogen gas inhalation courtesy of Chen, Jibing, et al. “Brain metastases completely disappear in non-small cell lung cancer using hydrogen gas inhalation: A case report.” OncoTargets and therapy (2019): 11145-11151.

Conclusion: These two case reports show remarkable clearing and sustained remission of metastatic brain lesions from Non Small Cell Lung Cancer (NSCLC) with inhalation of hydrogen gas, a treatment widely available with inexpensive home generators. I would like to see a larger series patients with NSCLC treated with hydrogen gas inhalation at a large tertiary care cancer referral center such as MD Anderson in Houston. Also, possible synergies with repurposed drugs could be explored with preclinical studies in animal xenografts and cell cultures. For example, one wonders about synergy of hydrogen gas with mebendazole, Ivermectin, Propranolol, Dichloroacetate, Niclosamide, Melatonin, Berberine, etc in animal cancer xenograft or cell  culture models.

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Jeffrey Dach MD
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References And Links

1) Xu, Kecheng, et al. “Explosive Progression of Brain Metastases from Lung Adenocarcinoma after Radiotherapy and Significant Reversal after Inhalation of Hydrogen-Oxygen Gas: A Case Report.” Ann Med Case Rep. 2022;4(1):1032.

Rationale: For multiple brain metastases complicated by Non-Small Cell Lung Cancer (NSCLC), Whole Brain Irradiation Therapy (WBRT) is the first choice for
treatment. But little is known about the explosive progression of brain metastases caused by radiotherapy and the reversal of hydrogen gas inhalation.
Patient concerns: A 51-year-old female patient was diagnosed with NSCLC with multiple brain metastases. After receiving Gefitinib and Osimertinib without
clinical response, she received 28 days of WBRT.
Diagnosis: One week after the end of WBRT, the patient’s general condition suddenly worsened, with severe headache, vomiting, confusion, and incontinence. MRI showed that the number and size of brain metastases increased explosively. Interventions and outcomes: In the absence of any special “anti-cancer” treatment available, the patient only receives hydrogen gas inhalation therapy, inhaling a mixture of hydrogen and oxygen (66% H2 and 34% O2), 3000 ml/min, at least 6 hours a day. The patient’s condition began to improve after a week, and markedly improved after one month. A reexamination of MRI showed that more than 90% of brain metastases disappeared.

Lessons: Radiotherapy is a double-edged sword. Doctors should pay attention to the adverse effects of radiotherapy, especially for brain metastases complicated
by lung cancer. Molecular hydrogen is a therapeutic gas that can selectively scavenge toxic free radicals, its role in cancer treatment is worthy of attention and
further research.

2) Chen, Jibing, et al. “Brain metastases completely disappear in non-small cell lung cancer using hydrogen gas inhalation: A case report.” OncoTargets and therapy (2019): 11145-11151.

Making Tumors Drop Off: Molecular Hydrogen Author: Daniel Stanciu, PhD Last update: Febraury 28th, 2021

Fu, Zhiling, and Jin Zhang. “Molecular hydrogen is a promising therapeutic agent for pulmonary disease.” Journal of Zhejiang University-SCIENCE B 23.2 (2022): 102-122.

Hirano, Shin-ichi, et al. “Molecular hydrogen as a novel antitumor agent: Possible mechanisms underlying gene expression.” International Journal of Molecular Sciences 22.16 (2021): 8724.

Noor, Muhammad Nooraiman Zufayri Mohd, et al. “A systematic review of molecular hydrogen therapy in cancer management.” Asian Pacific journal of cancer prevention: APJCP 24.1 (2023): 37.

Artamonov, Mikhail Yu, et al. “Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration.” Antioxidants 12.3 (2023).
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organoprotective effects;
minimization of the consequences of ischemic–reperfusion lesions;
limitation of systemic inflammatory responses;
antitumor effects;
anti-aging effects;
increasing the body’s resistance to stressors of various nature;
improved exercise tolerance.

Chen, Ji-Bing, You-Yong Lu, and Ke-Cheng Xu. “A narrative review of hydrogen oncology: from real world survey to real world evidence.” Medical Gas Research 10.3 (2020): 130.

Chen, Ji-Bing, et al. ““Real world survey” of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.” Medical Gas Research 9.3 (2019): 115-121.

Advanced cancer treatment is a huge challenge and new ideas and strategies are required. Hydrogen exerts antioxidant and anti-inflammatory effects that may be exploited to control cancer, the occurrence and progression of which is closely related to peroxidation and inflammation. We conducted a prospective follow-up study of 82 patients with stage III and IV cancer treated with hydrogen inhalation using the “real world evidence” method. After 3-46 months of follow-up, 12 patients died in stage IV. After 4 weeks of hydrogen inhalation, patients reported significant improvements in fatigue, insomnia, anorexia and pain. Furthermore, 41.5% of patients had improved physical status, with the best effect achieved in lung cancer patients and the poorest in patients with pancreatic and gynecologic cancers. Of the 58 cases with one or more abnormal tumor markers elevated, the markers were decreased at 13-45 days (median 23 days) after hydrogen inhalation in 36.2%. The greatest marker decrease was in achieved lung cancer and the lowest in pancreatic and hepatic malignancies. Of the 80 cases with tumors visible in imaging, the total disease control rate was 57.5%, with complete and partial remission appearing at 21-80 days (median 55 days) after hydrogen inhalation. The disease control rate was significantly higher in stage III patients than in stage IV patients (83.0% and 47.7%, respectively), with the lowest disease control rate in pancreatic cancer patients. No hematological toxicity was observed although minor adverse reactions that resolved spontaneously were seen in individual cases. In patients with advanced cancer, inhaled hydrogen can improve patients’ quality-of-life and control cancer progression. Hydrogen inhalation is a simple, low-cost treatment with few adverse reactions that warrants further investigation as a strategy for clinical rehabilitation of patients with advanced cancer. The study protocol received ethical approval from the Ethics Committee of Fuda Cancer Hospital of Jinan University on December 7, 2018 (approval  number: Fuda20181207).

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Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
my blog: www.jeffreydachmd.com 
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Published on May 14th, 2024 by Jeffrey Dach MD

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