The new 52 books at dc are much easier to grab onto than the pre-new 52 stuff,because there is less continuity and they are not so interlocked. Of those, Batman, Animal Man, Batwoman, Swamp Thing and Demon Knights are some of my favorites.
At marvel, Dan Slott’s Spider-man is awesome and is careful not to weigh you down with continuity. Anything by Marjorie m. Liu or Kelly Sue DeConnick or Jonathan Hickman will be outstanding.
For indies, I love Rachel Rising, Atomic Robo, and Chew.
Hope this helps…anyone else want to makeSomme suggestions?