End of the Englightenment?

 I've seen this come up a few times lately.Somebody synthesized perfluorocubane recently.  ("fluorinated esters as starting materials with dissolved fluorine gas in a perfluorinated solvent at low temperatures".)  Methodological naturalism is fine.  The philosophical framework of a knowable universe is fine, too.A whole bunch of other things are not at all fine, but all of those come down to