Super-precise CRISPR tool enhanced by enzyme engineering

By Heidi Ledford A super-precise version of the CRISPR genome-editing tool just got even better. Researchers have boosted the accuracy of a technique based on the popular but error-prone CRISPR–Cas9 system by engineering enzymes that can precisely target DNA without introducing as many unwanted mutations. The enzymes, reported on 10 February in Nature Biotechnology1, could make …