Psychedelics — Microdosing, Mind-Enhancing Methods, and More (#377)
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This episode features a panel that I moderated in front of a standing-room-only crowd at the Milken Institute’s Global Conference 2019. It includes a great overview of psychedelic science, investing opportunities, anecdotal personal benefits, legal challenges, and much more. I think it’s one of the more comprehensive panels ever done on the subject. Here are the participants:
Matthew Johnson — Principal Investigator, Johns Hopkins Psychedelic Research Unit
Ayelet Waldman — Author, A Really Good Day: How Microdosing Made a Mega Difference in My Mood, My Marriage, and My Life
Robin Carhart-Harris — Head of Psychedelic Research, Centre for Psychedelic Research, Department of Brain Sciences, Imperial College London
Christian Angermayer — Founder, Apeiron Investment Group and ATAI Life Sciences
Please enjoy!
Listen to the episode on Apple Podcasts, Spotify, Stitcher, Overcast, Castbox, or on your favorite podcast platform.
[image error] [image error] [image error] #377: Psychedelics — Microdosing, Mind-Enhancing Methods, and More
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Want to hear another podcast discussing psychedelics? — Listen to my conversation with James Fadiman, who has been called “America’s wisest and most respected authority on psychedelics and their use.” Stream below or right-click here to download.
Ep 66: The Psychedelic Explorer's Guide - Risks, Micro-Dosing, Ibogaine, and Morehttps://rss.art19.com/episodes/ae1b609a-106c-486e-a62b-2f4b410b33da.mp3Download
QUESTION(S) OF THE DAY: What was your favorite quote or lesson from this episode? Please let me know in the comments.
Scroll below for links and show notes…
SELECTED LINKS FROM THE EPISODE
Connect with Matthew Johnson:
Johns Hopkins Psychedelic Research Unit | Twitter
Connect with Ayelet Waldman:
Website | Twitter | Instagram | Facebook
Connect with Robin Carhart-Harris:
Centre for Psychedelic Research, Imperial College London | Twitter | Facebook
Connect with Christian Angermayer:
Apeiron Investment Group | ATAI Life Sciences | Twitter
Milken Institute
Milken Institute’s Global Conference 2019
Psychedelics: Mind-Enhancing Methods to Well-Being, Milken Institute
A Really Good Day: How Microdosing Made a Mega Difference in My Mood, My Marriage, and My Life by Ayelet Waldman
Here’s Why We Should Never Forget Katharine McCormick’s Special Role in the Birth Control Movement, History A2Z
Human Hallucinogen Research: Guidelines for Safety, Journal of Psychopharmacology
Psilocybin: An Overview, ScienceDirect
Drug Scheduling, DEA
The slides by Matthew Johnson can be found by clicking here.
The Abuse Potential of Medical Psilocybin According to the 8 Factors of the Controlled Substances Act, Neuropharmacology
Psilocybin Produces Substantial and Sustained Decreases in Depression and Anxiety in Patients with Life-Threatening Cancer: A Randomized Double-Blind Trial, Journal of Psychopharmacology
The Heretic, The Morning News
A New Chapter in the Science of Psychedelic Microdosing, The Atlantic
How New Ketamine Drug Helps with Depression, Yale Medicine
Pilot Study of the 5-HT2AR Agonist Psilocybin in the Treatment of Tobacco Addiction, Journal of Psychopharmacology
Open Label Study, MedicineNet
Chantix (Varenicline), RxList
Study Design 101, Himmelfarb, Health Sciences Library
Selective Serotonin Reuptake Inhibitors (SSRIs), The Mayo Clinic
A Case Against the Drug War, The Harvard Gazette
Burning Man
Ask the Doctor: What Is Hypomania? Harvard Medical School
The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs, Frontiers in Human Neuroscience
What is Serotonin? Hormone Health Network
Serotonin and Brain Function: A Tale of Two Receptors, Journal of Psychopharmacology
History of Psychedelics: How the Mazatec Tribe Brought Entheogens to the World, Psychedelic Times
Compass Pathways
R-ketamine: A Rapid-Onset and Sustained Antidepressant Without Psychotomimetic Side Effects, Translational Psychiatry
The FOMO Is Real: How Social Media Increases Depression and Loneliness, Healthline
What is MDMA? NIH
MDMA-Assisted Psychotherapy Study Protocols, MAPS
Ibogaine Therapy for Drug Addiction, MAPS
This Is How Ayahuasca Affects the Brain, Vice
Meaning of a Bad Trip, Verywell Mind
Syd’s First Trip: Home Footage of Pink Floyd Founder Syd Barrett’s First Experience with LSD, Happy Mag
What Is Hallucinogen-Persisting Perception Disorder (HPPD)? Medical News Today
Opiate, Opioid, Narcotic — What’s the Difference? IWP
Residential Psychedelic (LSD) Therapy for the Narcotic Addict, Archives Of General Psychiatry
Psilocybin-Facilitated Treatment for Cocaine Use by Peter Hendricks, University of Alabama at Birmingham
The Surprising Failures of 12 Steps, The Atlantic
Diagnostic And Statistical Manual Of Mental Disorders (DSM), American Psychiatric Association
Marcus Raichle on the Default Mode Network, VPRO Labyrint TV
Six NASA Astronauts Describe the Moment in Space When “Everything Changed” Inverse
Canyon Ranch
Exploring the Potential Recreational Psilocybin Market, Psychedelic Science Review
Calm
Fear-Setting: The Most Valuable Exercise I Do Every Month, tim.blog
Psilocybin-assisted Treatment for Alcohol Dependence: A Proof-of-Concept Study, Journal of Psychopharmacology
Tools of Titans: The Tactics, Routines, and Habits of Billionaires, Icons, and World-Class Performers by Timothy Ferriss
SHOW NOTES
An encouraging story about how well-funded research can change lives for the better. [03:25]
Matthew Johnson stresses how understanding the downsides and risks of psychedelics is key to their responsible use in research. (The slides by Matthew Johnson can be found by clicking here.) [06:02]
Matthew Johnson lays out the benefits, as we currently understand them, of psychedelics on mental health and addiction. [07:21]
How did Ayelet Waldman begin her experiences with microdosing, and in what ways did the practice affect her depression and productivity? [12:17]
Robin Carhart-Harris explains our current understanding of why these compounds do what they do — even beyond the duration of their physical presence — in what he describes as the entropic brain. [16:48]
Christian Angermayer tells us why his biotech company, ATAI Life Sciences, is currently one of the largest global investors in bringing psychedelics — including psilocybin — back into the legal realm. [21:37]
Treating PTSD with MDMA, how Ayelet and her husband use MDMA to process “the mundane PTSD of a long marriage,” and the risks involved. [28:16]
Matthew speaks to the potential toxicity of some of these compounds. [31:41]
Matthew takes us through current studies applying psychedelics to opiate and opioid addiction, and Ayelet weighs in on why traditional methods have not proven successful thus far, and why we need to reclassify some schedule one psychedelics to schedule four. [37:33]
Robin explains the context-shifting power psychedelics have over certain diagnostic categories, the problem with diagnostic categories as they traditionally stand, and current thinking around the default mode network. [40:45]
Why Christian believes psychedelics should be used in a strictly controlled environment by prescription rather than provided over the counter. [45:48]
Ayelet’s ideal paradigm for psychedelic decriminalization: the psychedelic spa. [47:04]
Christian points to The Netherlands as an example of a place where psychedelics are available recreationally, but not applied in a way that puts a dent in that country’s mental health crisis. [47:59]
How does Christian envision a sustainable business model for single-dose psychedelic therapies? [48:39]
How did these compounds come to be classified as schedule one drugs, and how can we potentially get them reclassified as schedule four drugs? Matthew has answers. [52:54]
What would Ayelet hope this field looks like a few years from now? [59:16]
PEOPLE MENTIONED
Katharine McCormick
Gregory Pincus
George Goldsmith
Sasha Shulgin
Ann Shulgin
Michael Chabon
Syd Barrett
Peter Hendricks
Tom Insel
Michael Bogenschutz
