"Irremediable Complexity"

An intriguing "hypothesis" paper entitled "How a neutral evolutionary ratchet can build cellular complexity"1, where the authors speculate about a possible solution to a possible problem, recently appeared in the journal IUBMB Life. It is an expanded version of a short essay called "Irremediable Complexity?"2 published last year in Science. The authors of the manuscripts include the prominent evolutionary biologist W. Ford Doolittle.

The gist of the paper is this. The authors think...