Zika Virus or Glyphosate Exposure Causing Microcephaly

Is It Zika Virus or Glyphosate Exposure ?

by Jeffrey Dach MD

Agricultural Chemical Exposure with Glyphosate Causes Microcephaly by Upregulating Retinoic (Vitamin A) Signalling

The news media has been reporting the Zika virus as the cause of microcephaly. However, another very likely consideration is exposure to Monsanto’s Round-Up Herbicide, glyphosate, which disrupts retinoic signalling.  Microcephaly describes the small head size in babies born to South American Agricultural workers. (1-4)   Header image:  Microephaly (smal head size)  in newborn dated Jan. 30, 2016  in Bonito, Pernambuco state, Brazil. courtesy of AP Photo/Felipe Dana (11)

Dr Alejandra Paganelli reported in 2010 that “Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling.” (8) Left image: baby born with microcephaly.  News media blames the Zika Virus courtesy of BBC News.

Dr Paganelli concludes: “(congenital malformations) “produced by Glyphosate Based Herbicides are mainly a consequence of the increase of endogenous retinoid activity. ” (8)

Dr Sylvia Lopez

In 2012, Dr Silvia L. Lopez reviewed the effects of agricultural chemicals, glyphosate based herbicides, in human and animal models.(9)  She says: “It is very well known that acute or chronic increase of retinoic acid (RA) levels leads to teratogenic effects during human pregnancy and in experimental models. The characteristic features displayed by Retinoic Acid embryopathy in humans include brain abnormalities such as microcephaly, microphtalmia, and impairment of hindbrain development; abnormal external and middle ears (microtia or anotia), mandibular and midfacial underdevelopment, and cleft palate.” (9) Note: Retinoic Acid is Vitamin A Derivative.  Left image aerial spraying of field with glyphosate.

Dr Benitez-Leite reported 52 cases of malformations in babies born of women exposed to agricultural chemicals. The congenital malformations observed include anencephaly, microcephaly, facial defects, myelomeningocele, cleft palate, ear malformations, polydactily, syndactily all consistent with the well-known and expected syndrome caused by upregulation of the RA pathway.(10)  Left image Monsanto’s Roundup herbicide contains glyphosate.

Conclusion:

The Zika Virus is a distraction from the real cause of the problem, the widely used agricultural herbicide, glyphosate.  The cause of microcephaly in babies born to South American Agricultural workers is glyphosate exposure which upregulates Retinoic Acid (Vitamin A) and is known to cause microcephaly in animal and human models.  Above Left image: Elephant in the Room is Glyphosate, courtesy of Stephanie Seneff PhD slide presentation.

Above left image: cellular retinoic acid signalling courtesy of Professor Peter McCaffery.

Link to this article: http://wp.me/p3gFbV-3En

Jeffrey Dach MD

7450 Griffin Road Suite 190

Davie, Fl 33314

954-792-4663

Articles with related interest:

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Links and references :

1)   Zika can cause microcephaly even if moms have no symptoms, report says  By Lena H. Sun June 15 Washington Post

2)  Zika: The Epidemic at America’s Door

Zika may have already infected 80,000 Americans, just in Puerto Rico, and Congress has refused to act — what if Miami or New York is next?  By Janet Reitman June 15, 2016 Rolling Stone

3)  June 14, 2016 Florida’s Zika threat: ‘Not our first rodeo’ with these mosquitoes Miami herald

4) Ho, Mae-Wan. “Lab study establishes glyphosate link to birth defects.” ISIS (2010).

5) Carrasco, Andrés. “Teratogenesis by glyphosate based herbicides and other pesticides. Relationship with the retinoic acid pathway.” GMLS 2012 (2013): 24.Teratogenesis by glyphosate based herbicides Carrasco 2012 program key note

6) Antoniou, M., et al. “Teratogenic effects of glyphosate-based herbicides: Divergence of regulatory decisions from scientific evidence.” Journal of Environmental & Analytical Toxicology 2012 (2012).

7) Dzialowski Ed THE EFFECTS OF GLYPHOSATE BASED HERBICIDES ON CHICK EMBRYO DEVELOPMENT Diss. UNIVERSITY OF NORTH TEXAS, 2013 thesis.  “The embryos had reduction in optic vesicles and microcephaly. Treated frog and chicken embryos also had increased endogenous retinoic acid activity,”

8) Paganelli, Alejandra, et al. “Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling.” Chemical research in toxicology 23.10 (2010): 1586-1595. Glyphosate herbicides produce teratogenic effects by impairing retinoic acid signaling Paganelli Alejandra Chemical research in toxicology 2010

we conclude that the phenotypes produced by GBH ( Glyphgosate Based Herbicides ) are mainly a consequence of the increase of endogenous retinoid activity

9) Pesticides Used in South American GMO-Based Agriculture: A Review of Their Effects on Humans and Animal Models Silvia L. Lopez 2012, Pesticides South American GMO Agriculture Effects on Humans Animals Silvia L Lopez Advances in Molecular Research 2012

10) Benítez-Leite, S., M. L. Macchi, and M. Acosta. “Congenital malformations associated with toxic agricultural chemicals.” Pediatría (Asunción) 34.2 (2007): 111-121.

11) Header Image:  Baby with Microcephaly Courtesy of Global News

In this Jan. 30, 2016 photo, Elielson tries to calm down his baby brother Jose Wesley, in Bonito, Pernambuco state, Brazil.

AP Photo/Felipe Dana

12) Comment by Mark WIlliam Houston on The Scientist

“I find it unusual that the Zika Virus, which comes from Uganda has never caused a single case of microcephaly in  a child born in Central Africa. Now it may be argued that the Brazilian Zika Virus is a mutated strain, but, the Zika Virus was first discovered in 1947, in the Zika Forest, Uganda, and as such already has hundreds of different strains. Remember, the Zika Virus has been part of the Zika Forest ecosystem for possibly thousands of years, yet still, there is not a single recorded case of a hominid microcephaly and or a case involving any other mammal the virus has infected.”

13)

Zika Microcephaly and the Problem with Smoking Gun Medicine Jun 9, 2016 by Chandler Marrs, PhD

14) THE QUESTIONABLE SCIENCE BEHIND ZIKA, MICROCEPHALY, & THE CDC   02 JUN 2016 POSTED BY ANTHONY TYLER

15)  Big Breaking News from the Zika Virus Hoax Front BY PAUL FASSA JUN 10 2016

16)  Rull, Rudolph P., Beate Ritz, and Gary M. Shaw. “Neural tube defects and maternal residential proximity to agricultural pesticide applications.” American journal of epidemiology 163.8 (2006): 743-753.

17) Lacasaña, Marina, et al. “Maternal and paternal occupational exposure to agricultural work and the risk of anencephaly.” Occupational and environmental medicine 63.10 (2006): 649-656.

18) Brender, Jean D., et al. “Maternal pesticide exposure and neural tube defects in Mexican Americans.” Annals of epidemiology 20.1 (2010): 16-22.

19) Schreinemachers, Dina M. “Birth malformations and other adverse perinatal outcomes in four US Wheat-producing states.” Environmental Health Perspectives 111.9 (2003): 1259.

20) Bell, E. M., I. Hertz-Picciotto, and J. J. Beaumont. “A case-control study of pesticides and fetal death due to congenital anomalies.” Epidemiology (Cambridge, Mass.) 12.2 (2001): 148.

Jeffrey Dach MD

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