Should I Self Publish My New Novel?

Should I self publish my new novel? New platforms? Stick with industry as before? Opinions?
Let me know what you think. I've published in the past with large NY-based companies. Everything in the industry is changing. I have nothing to prove re "getting published" but feel that with the new online ways to reach readers I may want to join the growing numbers of authors jumping out of the trade and go it alone. 

I've been working on a novel (funny) I started 17 years ago. I think I have a potential hit. But I also think I may know how to reach my readers in a better way than publishers will. 
On the other hand....
What do you think?