Curcumin is the active chemical in turmeric. Curcumin supplements are considered safe and no adverse side effects have been reported at low doses. One study in ten adults found that taking 490 mg of curcumin daily for a week caused no side effects.
Curcumin possesses antidepressant properties. A 2017 review looked at all the research on using turmeric — specifically, curcumin — to help treat depression. It found curcumin may indeed be a safe and effective natural treatment option. It increases the neurotransmitters dopamine and serotonin, but not norepinephrine, and has the potential to increase GABA.
Curcumin also possesses anti-inflammatory properties that can alleviate arthritis. But if you take it for this purpose, you must do so on an empty stomach.